1,552 research outputs found
Bayesian Sensitivity Analysis of Flight Parameters in a Hard-Landing Analysis Process
A flight parameter sensor simulation model was developed to assess the conservatism of the landing gear component loads calculated using a typical hard-landing analysis process. Conservatism exists due to factors of safety that are incorporated into any hard-landing analysis process to account for uncertainty in the measurement of certain flight parameters. The flight parameter sensor simulation model consists of 1) an aircraft and landing gear dynamic model to determine the “actual” landing gear loads during a hard landing; 2) an aircraft sensor and data acquisition model to represent the aircraft sensors and flight data recorder systems to investigate the effect of signal processing on the flight parameters; and 3) an automated hard-landing analysis process, representative of that used by airframe and equipment manufacturers, to determine the “simulated” landing gear loads. Using a technique of Bayesian sensitivity analysis, a number of flight parameters are varied in the flight parameter sensor simulation model to gain an understanding of the sensitivity of the difference between actual and simulated loads to the individual flight parameters in symmetric and asymmetric two-point landings. This study shows that the error can be reduced by learning the true value of the following flight parameters: longitudinal tire–runway friction coefficient, aircraft vertical acceleration (related to vertical descent velocity), lateral acceleration (related to lateral velocity), Euler roll angle, mass, center of gravity position, and main landing gear tire type. It was also shown that, due to the modeling techniques used, shock absorber servicing state and tire pressure do not contribute significantly to the error
Recovering the second moment of the strain distribution from neutron Bragg edge data
Point by point strain scanning is often used to map the residual stress
(strain) in engineering materials and components. However, the gauge volume and
hence spatial resolution is limited by the beam defining apertures and can be
anisotropic for very low and high diffraction (scattering) angles.
Alternatively, wavelength resolved neutron transmission imaging has a potential
to retrieve information tomographically about residual strain induced within
materials through measurement in transmission of Bragg edges - crystallographic
fingerprints whose locations and shapes depend on microstructure and strain
distribution. In such a case the spatial resolution is determined by the
geometrical blurring of the measurement setup and the detector point spread
function. Mathematically, reconstruction of strain tensor field is described by
the longitudinal ray transform; this transform has a non-trivial null-space,
making direct inversion impossible. A combination of the longitudinal ray
transform with physical constraints was used to reconstruct strain tensor
fields in convex objects. To relax physical constraints and generalise
reconstruction, a recently introduced concept of histogram tomography can be
employed. Histogram tomography relies on our ability to resolve the
distribution of strain in the beam direction, as we discuss in the paper. More
specifically, Bragg edge strain tomography requires extraction of the second
moment (variance about zero) of the strain distribution which has not yet been
demonstrated in practice. In this paper we verify experimentally that the
second moment can be reliably measured for a previously well characterised
aluminium ring and plug sample. We compare experimental measurements against
numerical calculation and further support our conclusions by rigorous
uncertainty quantification of the estimated mean and variance of the strain
distribution
The Open Source GAITOR Suite for Rodent Gait Analysis
Locomotive changes are often associated with disease or injury, and these changes can be quantified through gait analysis. Gait analysis has been applied to preclinical studies, providing quantitative behavioural assessment with a reasonable clinical analogue. However, available gait analysis technology for small animals is somewhat limited. Furthermore, technological and analytical challenges can limit the effectiveness of preclinical gait analysis. The Gait Analysis Instrumentation and Technology Optimized for Rodents (GAITOR) Suite is designed to increase the accessibility of preclinical gait analysis to researchers, facilitating hardware and software customization for broad applications. Here, the GAITOR Suite’s utility is demonstrated in 4 models: a monoiodoacetate (MIA) injection model of joint pain, a sciatic nerve injury model, an elbow joint contracture model, and a spinal cord injury model. The GAITOR Suite identified unique compensatory gait patterns in each model, demonstrating the software’s utility for detecting gait changes in rodent models of highly disparate injuries and diseases. Robust gait analysis may improve preclinical model selection, disease sequelae assessment, and evaluation of potential therapeutics
The Time-Domain Spectroscopic Survey: Understanding the Optically Variable Sky with SEQUELS in SDSS-III
The Time-Domain Spectroscopic Survey (TDSS) is an SDSS-IV eBOSS subproject
primarily aimed at obtaining identification spectra of ~220,000
optically-variable objects systematically selected from SDSS/Pan-STARRS1
multi-epoch imaging. We present a preview of the science enabled by TDSS, based
on TDSS spectra taken over ~320 deg^2 of sky as part of the SEQUELS survey in
SDSS-III, which is in part a pilot survey for eBOSS in SDSS-IV. Using the
15,746 TDSS-selected single-epoch spectra of photometrically variable objects
in SEQUELS, we determine the demographics of our variability-selected sample,
and investigate the unique spectral characteristics inherent in samples
selected by variability. We show that variability-based selection of quasars
complements color-based selection by selecting additional redder quasars, and
mitigates redshift biases to produce a smooth quasar redshift distribution over
a wide range of redshifts. The resulting quasar sample contains systematically
higher fractions of blazars and broad absorption line quasars than from
color-selected samples. Similarly, we show that M-dwarfs in the TDSS-selected
stellar sample have systematically higher chromospheric active fractions than
the underlying M-dwarf population, based on their H-alpha emission. TDSS also
contains a large number of RR Lyrae and eclipsing binary stars with
main-sequence colors, including a few composite-spectrum binaries. Finally, our
visual inspection of TDSS spectra uncovers a significant number of peculiar
spectra, and we highlight a few cases of these interesting objects. With a
factor of ~15 more spectra, the main TDSS survey in SDSS-IV will leverage the
lessons learned from these early results for a variety of time-domain science
applications.Comment: 17 pages, 14 figures, submitted to Ap
MRI in multiple myeloma : a pictorial review of diagnostic and post-treatment findings
Magnetic resonance imaging (MRI) is increasingly being used in the diagnostic work-up of patients with multiple myeloma. Since 2014, MRI findings are included in the new diagnostic criteria proposed by the International Myeloma Working Group. Patients with smouldering myeloma presenting with more than one unequivocal focal lesion in the bone marrow on MRI are considered having symptomatic myeloma requiring treatment, regardless of the presence of lytic bone lesions. However, bone marrow evaluation with MRI offers more than only morphological information regarding the detection of focal lesions in patients with MM. The overall performance of MRI is enhanced by applying dynamic contrast-enhanced MRI and diffusion weighted imaging sequences, providing additional functional information on bone marrow vascularization and cellularity. This pictorial review provides an overview of the most important imaging findings in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma, by performing a 'total' MRI investigation with implications for the diagnosis, staging and response assessment. Main message aEuro cent Conventional MRI diagnoses multiple myeloma by assessing the infiltration pattern. aEuro cent Dynamic contrast-enhanced MRI diagnoses multiple myeloma by assessing vascularization and perfusion. aEuro cent Diffusion weighted imaging evaluates bone marrow composition and cellularity in multiple myeloma. aEuro cent Combined morphological and functional MRI provides optimal bone marrow assessment for staging. aEuro cent Combined morphological and functional MRI is of considerable value in treatment follow-up
Serine-Selective Bioconjugation.
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method tolerates all other known nucleophilic functional groups of naturally occurring proteinogenic amino acids. A variety of applications can be envisaged by this expansion of the toolbox of site-selective bioconjugation methods
Beam-Induced Nuclear Depolarisation in a Gaseous Polarised Hydrogen Target
Spin-polarised atomic hydrogen is used as a gaseous polarised proton target
in high energy and nuclear physics experiments operating with internal beams in
storage rings. When such beams are intense and bunched, this type of target can
be depolarised by a resonant interaction with the transient magnetic field
generated by the beam bunches. This effect has been studied with the HERA
positron beam in the HERMES experiment at DESY. Resonances have been observed
and a simple analytic model has been used to explain their shape and position.
Operating conditions for the experiment have been found where there is no
significant target depolarisation due to this effect.Comment: REVTEX, 6 pages, 5 figure
Measurement of the Spin Asymmetry in the Photoproduction of Pairs of High-pT Hadrons at HERMES
We present a measurement of the longitudinal spin asymmetry A_|| in
photoproduction of pairs of hadrons with high transverse momentum p_T. Data
were accumulated by the HERMES experiment using a 27.5 GeV polarized positron
beam and a polarized hydrogen target internal to the HERA storage ring. For
h+h- pairs with p_T^h_1 > 1.5 GeV/c and p_T^h_2 > 1.0 GeV/c, the measured
asymmetry is A_|| = -0.28 +/- 0.12 (stat.) +/- 0.02 (syst.). This negative
value is in contrast to the positive asymmetries typically measured in deep
inelastic scattering from protons, and is interpreted to arise from a positive
gluon polarization.Comment: 5 pages (latex), 4 figures (eps
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